Detection method of sugammadex sodium

The invention relates to a method for detecting sugammadex sodium, which comprises the following steps of: respectively detecting a test sample solution and a reference substance solution by using a high performance liquid chromatograph under the chromatographic conditions that: a chromatographic co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BAI JUNPENG, WANG JINGYI, HE XIAOXIA, XIAO YU, WANG ZHENG, HU BAIYAN, WANG QI, WANG LICHUN, WU LEI, WU QING, JIN JINGJING, MENG QIUYUE
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a method for detecting sugammadex sodium, which comprises the following steps of: respectively detecting a test sample solution and a reference substance solution by using a high performance liquid chromatograph under the chromatographic conditions that: a chromatographic column is a C18 chromatographic column; a mobile phase A is a phosphate buffer solution with the concentration of 5 mmol/L to 40 mmol/L or a phosphoric acid aqueous solution with the volume concentration of 0.1 percent to 1.0 percent, and the pH value of the mobile phase A is 2.0 to 2.9; a mobile phase B is acetonitrile; the column temperature of the chromatographic column is 30-45 DEG C; the flow rate is 0.6 ml/min to 1.2 ml/min; and the wavelength of the ultraviolet detection is 190 nm to 210 nm. According to the detection method of sugammadex sodium provided by the invention, sugammadex sodium related substances can be effectively separated, the sensitivity is high, the specificity is good,and the accuracy is high