Detection method of sugammadex sodium
The invention relates to a method for detecting sugammadex sodium, which comprises the following steps of: respectively detecting a test sample solution and a reference substance solution by using a high performance liquid chromatograph under the chromatographic conditions that: a chromatographic co...
Gespeichert in:
Hauptverfasser: | , , , , , , , , , , , |
---|---|
Format: | Patent |
Sprache: | chi ; eng |
Schlagworte: | |
Online-Zugang: | Volltext bestellen |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The invention relates to a method for detecting sugammadex sodium, which comprises the following steps of: respectively detecting a test sample solution and a reference substance solution by using a high performance liquid chromatograph under the chromatographic conditions that: a chromatographic column is a C18 chromatographic column; a mobile phase A is a phosphate buffer solution with the concentration of 5 mmol/L to 40 mmol/L or a phosphoric acid aqueous solution with the volume concentration of 0.1 percent to 1.0 percent, and the pH value of the mobile phase A is 2.0 to 2.9; a mobile phase B is acetonitrile; the column temperature of the chromatographic column is 30-45 DEG C; the flow rate is 0.6 ml/min to 1.2 ml/min; and the wavelength of the ultraviolet detection is 190 nm to 210 nm. According to the detection method of sugammadex sodium provided by the invention, sugammadex sodium related substances can be effectively separated, the sensitivity is high, the specificity is good,and the accuracy is high |
---|