Use of aucubin in preparing medicine for treating type 2 diabetes

The invention belongs to the technical field of medicine, and provides the use of aucubin in preparing a medicine for treating type 2 diabetes. A mouse model of type 2 diabetes is established by intraperitoneal injection of streptozotocin after 4 weeks of a high-fat diet. Then, aucubin is injected i...

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Bibliographische Detailangaben
Hauptverfasser: LIU YAJUN, WANG NING, ZHOU YURONG, XUE HONGYU, XU PINSAN, MAO CHENCHEN, JIANG LILI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of medicine, and provides the use of aucubin in preparing a medicine for treating type 2 diabetes. A mouse model of type 2 diabetes is established by intraperitoneal injection of streptozotocin after 4 weeks of a high-fat diet. Then, aucubin is injected intraperitoneally at low, medium and high doses for 4 weeks respectively, four items of body weight,fasting blood glucose, insulin and blood lipid of mice are detected, the insulin resistance index and insulin sensitivity index are calculated, and the morphological changes of islets in pancreas areobserved by HE staining. The results show that the levels of insulin, TG, T-CHO and LDL-C in the serum of the mouse model of type 2 diabetes can be reduced, the level of HDL-C can be increased, and the insulin resistance index and insulin sensitivity index can be improved by aucubin in low, medium, and high doses of groups, compared with the model group. The atrophy of islets in the pancreas of the model mouse of type 2 di