Recombinant fused polypeptide and application thereof

The invention discloses a recombinant fused polypeptide and a preparation method and application thereof. The recombinant fused polypeptide is expressed by the following general formula: X-linker 1-Y;Y-linker 1-X; X-linker 2-Y; Y-linker 2-X, wherein X is PRCWRGEGGGGIVRRADRAAVPGGGGRGD; Y is Acetyl- SDKPGGGGTSLDASIIWAMMQNGGGGLSKL. The recombinant fused polypeptide of the invention can be used for treating various fibrotic diseases and symptoms, and can be used for treating pulmonary fibrosis, hepatic fibrosis, skin fibrosis, renal fibrosis, myocardial fibrosis and pulmonary tissue lesions. 本发明公开了一种重组融合多肽及其制备方法和其应用。一种重组融合多肽，所述的重组融合多肽由以下通式表述：X-linker1-Y；Y-linker1-X；X-linker2-Y；Y-linker2-X；其中X为：PRCWRGEGGGGIVRRADRAAVPGGGGRGD；Y为：Acetyl-SDKPGGGGTSLDASIIWAMMQNGGGGLSKL。本发明的重组融合多肽可以治疗各种纤维化疾病及病状，治疗用途包括抗肺纤维化、肝纤维化、皮肤纤维化、肾纤维化和心肌纤维化以及肺部组织病变。