ELECTROCHEMICAL DEPROTECTION FOR SITE-SELECTIVE IMMOBILIZATION AND LOCAL ASSEMBLY OF MOLECULES BY CLICK-CHEMISTRY

A method and devices for deprotecting anchored molecular compounds is provided which relies on an electrically addressable surface S with multiple compounds C thereon. Each compound C comprises threedistinct moieties, including: a first moiety A, anchored to the surface S; a second moiety, which comprises an acetylene unit U, that is a molecular backbone bonded to the first moiety; and a third moiety P, which is a protection moiety for acetylene. The protection moiety P is bonded to the acetylene unit U of the second moiety via an electrochemically breakable bond. The surface S is submerged in an electrolyte, so that the compounds C are immersed in the electrolyte. The protection moiety P of at least a subset of the compounds C can be electrochemically cleaved by applying an electric potential between the surface S and the electrolyte, so as to obtain cleaved compounds C' with free acetylene terminals. 本发明涉及用于位点选择性固定的电化学脱保护和通过点击化学的分子局部组装。提供了一种用于使锚定的分子化合物脱保护的方法和装置，其依赖于在其上具有多个化合物C的可电寻址表面S。每个化合物C包含三个不同的部分，包括：第一部