Preparation method of 4-propythio-2-nitroaniline

The invention discloses a preparation method of 4-propythio-2-nitroaniline, and solves the technical problems of unreasonable preparation method, high raw material price, high toxicity, complex operation, high cost, large production of three wastes, low yield and unsuitability for industrial production in the prior art. The preparation method of 4-propythio-2-nitroaniline provided by the inventiontakes o-nitroaniline, disulfur dichloride and chloropropane as the raw materials, and carries out condensation reaction and alkylation reaction in order under the action of a catalyst so as to obtain4-propythio-2-nitroaniline. The method can be widely applied technical field of synthesis of albendazole. 本发明公开了一种4-丙硫基-2-硝基苯胺的制备方法，其解决了现有制备方法不合理，存在原料价格昂贵且毒性大、操作复杂、成本高、三废产量大、收率低、不适合工业化生产的技术问题，本发明4-丙硫基-2-硝基苯胺的制备方法，以邻硝基苯胺、二氯化二硫、氯丙烷为原料，在催化剂作用下，依次经过缩合反应、烷基化反应，得到4-丙硫基-2-硝基苯胺，可广泛应用于阿苯达唑的合成技术领域。