Triazolo pyrazine compound containing heteroaryl substituted pyridazinone structure, and preparation method and applications thereof

The invention relates to a triazolo pyrazine compound containing a heteroaryl substituted pyridazinone structure, and pharmaceutically acceptable salts, hydrates, solvates, and a prodrug thereof, wherein the triazolo pyrazine compound containing a heteroaryl substituted pyridazinone structure is represented by general formula I, substation groups R1, R2, X, and Y are defined in the patent specification. The invention also relates to applications of the high inhibition effect of the compound represented by formula I on c-Met kinases , and applications of the triazolo pyrazine compound, and thepharmaceutically acceptable salts, hydrates, solvates, or the prodrug in preparation of drugs used for treating diseases induced by c-Met, EGFR, Flt-3 kinase abnormal high expression, and especially applications in preparation of drugs used in treatment and/or prevention of cancers. 本发明涉及通式Ⅰ所示的含杂芳基取代哒嗪酮结构的三唑并吡嗪类化合物及其药学上可接受的盐、水合物、溶剂化物和前药，其中取代基R、R、X、和Y具有在说明书中给出的含义。本发明还涉及通式Ⅰ的化合物具有强的抑制c-Met激酶的作用，并且还涉及该类化合物及其药学上可接受的盐、水合物、溶剂化物或