PROCESS FOR PREPARING 2-EXO-(2-METHYLBENZYLOXY)-1-METHYL-4-ISOPROPYL-7-OXABICYCLO[2.2.1]HEPTANE
This invention relates to a process for preparing (+/-)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) (I), any of its individual enantiomers or any non-racemic mixture thereof, comprising the step of reacting (+/-)-2-exo-hydroxy-1-methyl-4-isopropyl-7-o...
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Sprache: | chi ; eng |
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Zusammenfassung: | This invention relates to a process for preparing (+/-)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) (I), any of its individual enantiomers or any non-racemic mixture thereof, comprising the step of reacting (+/-)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) (II), any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) (III), wherein X is a leaving group, in the presence of at least one base, at least one catalyst selected from rubidium salts, cesium salts and any combination thereof and at least one inert organic solvent S1.
本发明涉及一种制备式(I)的(±)-2-外-(2-甲基苄氧基)-1-甲基-4-异丙基-7-氧杂二环[2.2.1]庚烷、任何其单独对映体或其任何非外消旋混合物的方法,所述方法包括使式(II)的(±)-2-外-羟基-1-甲基-4-异丙基-7-氧杂二环[2.2.1]庚烷与其中X为离去基团的式(III)的2-甲基苄基化合物在至少一种碱、至少一种选自铷盐、铯盐及其任何组合的催化剂和至少一种惰性有机溶剂S1存在下反应的步骤。 |
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