Polypeptide and application thereof

The invention discloses an application of a polypeptide and belongs to the field of biological pharmacy. The polypeptide is characterized in that the polypeptide contains the following structural domains: Pro-Arg-Cys-X-Y-Gly-Glu, wherein the X is Trp or Tyr and the Y is Arg or Cys; and Arg-Gly-Ala-Asp-Arg-Ala, or a sequence in which any amino acid in the above domains is mutated. The polypeptide can be used for treating various fibrotic diseases and symptoms including pulmonary fibrosis, hepatic fibrosis, myelofibrosis, renal fibrosis and myocardial fibrosis, skin fibrosis and pulmonary tissuepathological changes. 本发明公开了一种多肽的应用，属于生物制药领域。1.一种多肽，其特征在于，多肽中含有的结构域Pro-Arg-Cys-X-Y-Gly-Glu，其中X是Trp或Tyr;Y是Arg或Cys；和Arg-Gly-Ala-Asp-Arg-Ala；或者上述结构域中突变其中的任意氨基酸后的序列；可以治疗各种纤维化疾病及病状，包括肺纤维化、肝纤维化、骨髓纤维化、肾纤维化和心肌纤维化、皮肤纤维化以及肺部组织病变。