A pharmaceutical composition comprising rosuvastatin and ezetimibe and a preparation method thereof

The invention relates to a pharmaceutical composition comprising the active ingredients rosuvastatin of formula I, with the systematic name (3R,5S,6E)-7-[4-(4-fluorophenyl)-2-(N-methylmethanesulfonamido)-6-(propan-2--yl)pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable salts, esters, hydrates or solvates, and ezetimibe of formula II, with the systematic name (3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3--hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one or its pharmaceutically acceptable salts, esters, hydrates or solvates, as well as a preparation method of this pharmaceutical composition. The weight ratio of the layers is 1:2 to 2:1. 本发明涉及一种药物组合物，该药物组合物包含活性成分式I的瑞舒伐他汀，其系统名称为(3R,5S,6E)-7-[4-(4-氟苯基)-2-(N-甲基甲磺酰氨基)-6-(丙-2-基)嘧啶-5-基]-3,5-二羟基庚-6-烯酸，或其药学上可接受的盐、酯、水合物或溶剂化物，和式II的依泽替米贝，其系统名称为(3R,4S)-1-(4-氟苯基)-3-[(3S)-3-(4-氟苯基)-3-羟基丙基]-4-(4-羟基苯基)氮杂环丁烷-2-酮，或其药学上可接受的盐、酯、水合物或溶剂化物；以及这种药物组合物的一种制备方法。各层的重量比为1:2至2:1。