Application of ibrutinib in preparation of drugs for treating chronic hypoxic pulmonary hypertension

The invention discloses application of ibrutinib in preparation of drugs for treating chronic hypoxic pulmonary hypertension. The experimental result shows that rising of right ventricular pressure can be significantly alleviated by using the ibrutinib to treat rats in a hypoxic group, an HE staining result shows that the thickness increasing degree of pulmonary artery medial membranes of the ratsin the hypoxic group treated by the ibrutinib is alleviated, and the number of muscularized arterioles is decreased significantly. The ibrutinib can provide a potential treatment prospect for treatment of the chronic hypoxic pulmonary hypertension. 本发明公开了依鲁替尼在制备治疗慢性低氧性肺动脉高压药物的用途，实验结果表明，依鲁替尼治疗缺氧组大鼠可以明显减轻右心室压升高，HE染色结果显示依鲁替尼治疗缺氧组大鼠肺动脉中膜厚度增厚程度减轻，肌化小动脉数目明显减少。依鲁替尼可以为治疗慢性低氧性肺动脉高压提供潜在的治疗前景。