Synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid

Synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid

The invention discloses a synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid. The method is characterized in that 2,3,4,6-O-acetyl-alpha-D-mannopyranose trichloroacetimidate and allyloxy triethylene glycol are used for synthesizing epoxy...

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Hauptverfasser: CAI YEQIANG, MAO LINGMIAO, SUN LEI, YANG MEI, XING JINJING, ZHENG HAIFU, SONG DONGLIANG, YAO CHENG, MAO SHUONAN, MA YUMING, WANG YIKUN
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Sprache:chi ; eng
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CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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creator CAI YEQIANG
MAO LINGMIAO
SUN LEI
YANG MEI
XING JINJING
ZHENG HAIFU
SONG DONGLIANG
YAO CHENG
MAO SHUONAN
MA YUMING
WANG YIKUN
description The invention discloses a synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid. The method is characterized in that 2,3,4,6-O-acetyl-alpha-D-mannopyranose trichloroacetimidate and allyloxy triethylene glycol are used for synthesizing epoxypropyl triethylene glycol acyl mannose in the serial reaction in which chloroperoxybenzoic acid MCPBA and trimethylsilyl trifluoromethanesulfonate TMSOTf are adopted as catalysts; the mannose derivative is sequentially mixed with cetyl alcohol and triphenyl heptadecyl methanesulfonate, and triphenyl-dihexadecyl polyethylene glycol mannose is synthesized by taking sodium hydride as a strong base and adopting boron trifluoride diethyl ether BF3-C2H6O and tetrabutylammonium iodide TABI as catalysts; finally, triphenyl-dihexadecyl polyethylene glycol mannose is mixed with trifluoroacetic acid TFA under the condition of sodium superbase blocks and subjected to a reaction under the catalysis of aphase transfer catalyst b
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The method is characterized in that 2,3,4,6-O-acetyl-alpha-D-mannopyranose trichloroacetimidate and allyloxy triethylene glycol are used for synthesizing epoxypropyl triethylene glycol acyl mannose in the serial reaction in which chloroperoxybenzoic acid MCPBA and trimethylsilyl trifluoromethanesulfonate TMSOTf are adopted as catalysts; the mannose derivative is sequentially mixed with cetyl alcohol and triphenyl heptadecyl methanesulfonate, and triphenyl-dihexadecyl polyethylene glycol mannose is synthesized by taking sodium hydride as a strong base and adopting boron trifluoride diethyl ether BF3-C2H6O and tetrabutylammonium iodide TABI as catalysts; finally, triphenyl-dihexadecyl polyethylene glycol mannose is mixed with trifluoroacetic acid TFA under the condition of sodium superbase blocks and subjected to a reaction under the catalysis of aphase transfer catalyst b</description><language>chi ; eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20191022&amp;DB=EPODOC&amp;CC=CN&amp;NR=110357930A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20191022&amp;DB=EPODOC&amp;CC=CN&amp;NR=110357930A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CAI YEQIANG</creatorcontrib><creatorcontrib>MAO LINGMIAO</creatorcontrib><creatorcontrib>SUN LEI</creatorcontrib><creatorcontrib>YANG MEI</creatorcontrib><creatorcontrib>XING JINJING</creatorcontrib><creatorcontrib>ZHENG HAIFU</creatorcontrib><creatorcontrib>SONG DONGLIANG</creatorcontrib><creatorcontrib>YAO CHENG</creatorcontrib><creatorcontrib>MAO SHUONAN</creatorcontrib><creatorcontrib>MA YUMING</creatorcontrib><creatorcontrib>WANG YIKUN</creatorcontrib><title>Synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid</title><description>The invention discloses a synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid. 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subjects CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
title Synthesis method of mono-sulfhydryl bis-hexadecyl ether polyethylene glycol interchain oligosaccharide glycolipid
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