SUBSTITUTED PYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS

The invention discloses chemical entity of Formula (I) in which V, W, Y, and Z have any of the values described herein, and compositions comprising such chemical entities, methods of making them; andtheir use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques, radioactive treatments; modulating and treating disorders mediated by PDE2 activity; treating neurological disorders, CNS disorders, dementia, cognitive disorders, neurodegenerative diseases, and trauma-dependent losses of function, enhancing the efficiency of cognitive and motor training, including in stroke or TBI rehabilitation; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, dermatoiogical, inflammatory, and pain disorders. 通式(I)的化学实体：其中V、W、Y和Z具有本文所述的任何值，和包含此化学实体的组合物，制备它们的方法；以及它们在各种方法中的应用，包括代谢和反应动力学研究；检测和成像技术；放射性治疗；调节和治疗由PDE2活性介导的病症；治疗神经学病症、CNS病症、痴呆、认知障碍、神经退行性疾病和创伤依赖性功能丧失；提高包括脑卒中或TBI康复中的训练在内的认知和运动训练的效率；并且治疗外周病症，包括血液学病症、心血管病症、胃肠道病学病症、皮肤病学病症、炎症