MARKER FOR DETECTING HIGHLY PATHOGENIC INFLUENZA VIRUS AND USE THEREOF

The present invention relates to a marker for detecting a highly pathogenic influenza virus and a use thereof, and more particularly, to a marker for detecting a highly pathogenic influenza virus, which includes a protein mutant prepared by substituting the amino acids 68 and 69 of a PB1-F2 protein, a composition for detecting a highly pathogenic virus, which includes an agent for measuring the protein mutant, and a detection kit including the same, a method for detecting a highly pathogenic virus, which includes measuring the protein mutant, an antiviral composition against influenza A virus,which includes an inhibitor of binding between a PB1-F2 protein in which the amino acids 68 and 69 are substituted and DDX3, and a method for screening an antiviral substance against influenza A virus. In the present invention, as the correlation between a 1918 PB1-F2 protein and high pathogenicity of the virus and a molecular mechanism thereof were first identified, a protein mutant prepared bysubstituting the amino aci