Metronidazole sodium chloride injection and preparation method thereof

The invention discloses a metronidazole sodium chloride injection and a preparation method thereof. The metronidazole sodium chloride injection is characterized in that each 100 milliliters of injection comprises the following components of (1) 350-700 milligrams of metronidazole, (2) 600-1100 milli...

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Bibliographische Detailangaben
Hauptverfasser: ZHAO YANING, YIN DIANSHU, WANG LIJIANG, ZHANG YULING, YUAN GUANGFENG, LI SHILEI
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses a metronidazole sodium chloride injection and a preparation method thereof. The metronidazole sodium chloride injection is characterized in that each 100 milliliters of injection comprises the following components of (1) 350-700 milligrams of metronidazole, (2) 600-1100 milligrams of sodium chloride, (3) 35.0-69.0 milligrams of anhydrous disodium hydrogen phosphate, (4) 12.0-30.0 milligrams of anhydrous citric acid with the pH of 5.4-6.3; the preparation method comprises the following steps that (1) newly prepared injection water accounting for 25-40% of the total preparation volume is added into a thick preparation tank, the metronidazole, the sodium chloride, the anhydrous disodium hydrogen phosphate and the anhydrous citric acid are added according to the prescription volume, and after stirring and dissolution are carried out, the mixture is filtered to a thin preparation tank; (2) the injection water is added to a constant volume, stirring and uniform mixingare carried out, the con