Anti-inflammatory polypeptide nano drug and preparation method thereof

The invention discloses an anti-inflammatory polypeptide nano drug and a preparation method thereof. The anti-inflammatory polypeptide nano drug comprises anti-inflammatory polypeptides, a pH or reactive oxygen responsive material, phospholipids and polyethylene glycol-distearoyl phosphatidylethanolamine, wherein the anti-inflammatory polypeptide comprises the active N-terminal peptide Ac2-26 of annexin A1 and the tissue protective polypeptide ARA290; the mass ratio of the anti-inflammatory polypeptide to the pH or active oxygen responsive material is 0.01:1 and 2:1, the mass ratio of polyethylene glycol-distearoyl phosphatidylethanolamine to the pH or reactive oxygen responsive material is 0.02:1 and 2.5:1, and the mass ratio of polyethylene glycol-distearoyl phosphatidylethanolamine to phospholipid is 0.01:1 and 1:0.01. The drug can be used in preparation of preventive and therapeutic drugs for acute and chronic inflammation-related diseases. An administration method includes oral administration, intravenou