Lipoic acid derivatives and preparation method and application thereof

The invention discloses lipoic acid derivatives and a preparation method and application thereof, and belongs to the field of drug synthesis. Derivatization of the chemical structure of lipoic acid iscarried out, amines are introduced into the structure of the lipoic acid, the structures of the lipoic acid derivatives are quite different from the structure of the lipoic acid, and a good hypoglycemic effect is achieved. The preparation method of the lipoic acid derivatives is also provided. The method comprises the steps of adopting the lipoic acid and the amines as raw materials and N'N-carbonyl diimidazole as a condensing agent, adding the amines for a reaction for 12 hours after adding the lipoic acid, the N'N-carbonyl diimidazole and tetrahydrofuran at the room temperature for activation for 0.5 hour, and then carrying out column chromatography to obtain the lipoic acid derivatives. The preparation method is simple in operation, target compounds are obtained through the one-step reaction, the yield is high