Preparation method of low-energy consumption easy-industrial production high-purity dihydroartemisinic acid

The invention belongs to the field of medicinal chemistry, and particularly relates to a preparation method of low-energy consumption easy-industrial production high-purity dihydroartemisinic acid. The method comprises the following steps: (1) performing extraction concentration; (2) performing extr...

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Hauptverfasser: LIAO SHUQIAO, PENG GUOPING, OUYANG BIN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the field of medicinal chemistry, and particularly relates to a preparation method of low-energy consumption easy-industrial production high-purity dihydroartemisinic acid. The method comprises the following steps: (1) performing extraction concentration; (2) performing extraction; (3) performing acidification; (4) performing extraction; (5) performing concentration; (6) performing primary crystallization; (7) performing decolorization; (8) performing recrystallization; and (9) performing drying. According to the preparation method of the dihydroartemisinic acid provided by the invention, the steps of extraction concentration, extraction and acidification do not need heating, the operation temperature is room temperature, heating is required only when reagents arerecovered, so that the energy consumption is lower; the preparation method does not need column chromatography, does not need to add special equipment, and has smaller investment, simple operation, and easy industrialization