Chitosan wrapped matrine phenolate nano liposome and preparation method and application thereof

The invention discloses chitosan wrapped matrine phenolate nano liposome and a preparation method and application thereof. The nano liposome comprises, by weight, 0.1-5 parts of matrine phenolate, 0.5-5 parts of chitosan, 5-40 parts of lecithin, 10-20 parts of cholesterol and 1-100 parts of glycerin. The preparation method includes following steps: S1, heating lecithin, cholesterol and glycerin till being completely dissolved, sterilizing, and adding alcohol to obtain a mixed solution; S2, slowly injecting matrine phenolate into the mixed solution; S3, putting into a high-pressure homogenizerfor treatment; S4, adding chitosan into a phenolic acid water solution to obtain a chitosan water solution; S5, dropwise adding nano liposome into the chitosan water solution while stirring, and standing to obtain the chitosan wrapped matrine phenolate nano liposome. Cosmetics added with the nano liposome have good antioxidation and moisturizing effects. 本发明公开了一种壳聚糖包裹苦参碱酚酸盐纳米脂质体及其制备方法与应用，所述纳米脂质体的制备原料包含以下重量份数的组分：苦参碱酚酸盐：0.1