Phenylpiperazine type UBE2F small molecule inhibitor and synthesis method thereof

The invention discloses a phenylpiperazine type UBE2F small molecule inhibitor and a synthesis method thereof, discloses a phenylpiperazine type compound represented by the general formula I or a pharmaceutically acceptable salt thereof, and further discloses a synthesis route of the general formula I and a synthesis method of each step. As a small molecule inhibitor target at UBE2F, that phenylpiperazine type compound of the present invention effectively suppresses the growth of tumor cell by preventing the G2/M process of cell cycle and inducing apoptosis of human tumor cells. Therefore, thecompound is a new class of specific anti-tumor drugs by targeting UBE2F. 本发明为一种苯基哌嗪类UBE2F小分子抑制剂及其合成方法，公开了一种通式I所示的苯基哌嗪类化合物或其药学上可接受的盐，并进一步公开了所述通式Ⅰ的合成路线及各步骤的合成方法。本发明苯基哌嗪类化合物为靶向UBE2F的小分子抑制剂，对人源肿瘤细胞通过阻止细胞周期G2/M进程和诱导细胞凋亡，从而有效抑制肿瘤细胞生长。因此该化合物是一类新的、通过靶向UBE2F的特异性抗肿瘤药物。