Infected mouse model for lung delivery through liquid aerosol with plague bacilli

The invention discloses an infected mouse model for lung delivery through liquid aerosol with plague bacilli and provides a method for preparing an animal model. The method comprises the following steps that pathogenic bacteria are delivered to the animal lung through a liquid aerosol mode, and the animal model is obtained. The pathogenic bacteria are plague bacilli; or the animal is a mouse. According to the model, a test sample is directly delivered to the mouse lung through the liquid aerosol mode, a novel pulmonary plague mouse infection model is established, the model is high in targetingperformance and good in repeatability, and the infection condition of the test sample on the mouse can be accurately and quantitatively researched. 本发明公开了鼠疫菌液体气溶胶肺递送感染小鼠模型。本发明提供了一种制备动物模型的方法，包括如下步骤：通过液体气溶胶的方式将病原菌递送至动物的肺部，得到动物模型。所述病原菌为鼠疫菌；或所述动物为小鼠。本发明直接将受试物以气溶胶形式递送至小鼠肺部，构建了一种新的肺鼠疫小鼠感染模型，该模型针对性强，重复性好，可以准确定量研究受试物对小鼠的感染情况。