MUTANT NITRILE HYDRATASE, NUCLEIC ACID CODING SAID MUTANT NITRILE HYDRATASE, EXPRESSION VECTOR AND TRANSFORMANT INCLUDING SAID NUCLEIC ACID, PRODUCTION METHOD FOR SAID MUTANT NITRILE HYDRATASE, AND PRODUCTION METHOD FOR AMIDE COMPOUND

A nitrile hydratase that is derived from Pseudonocardia thermopila and has an alpha subunit and a beta subunit, wherein a specific amino acid residue has been substituted for the amino acid residue inat least one position selected from the group consisting of the 40th and 43rd residues from the N terminal of the alpha subunit, and the 205th, 206th and 215th residues from the N terminal of the beta subunit. 突变型腈水合酶，其是包含α亚基和β亚基的来源于嗜热假诺卡氏菌的腈水合酶，所述突变型腈水合酶中含有选自由α亚基的N末端起第40位及第43位以及β亚基的N末端起第205位、第206位及第215位组成的组中的至少1个位置处的氨基酸残基取代为特定氨基酸残基的取代。