VIRUS-LIKE PARTICLES WITH HIGH-DENSITY COATING FOR INDUCING THE EXPRESSION OF ANTIBODIES

The invention relates to a fusion protein comprising a polypeptide of interest, a transmembrane domain and an HIV gag polypeptide, or their functionally equivalent variants. The invention also relatesto the polynucleotides, vectors, host cells and virus-like particles expressing or presenting said fusion proteins and to the pharmaceutical, immunogenic or vaccines composition containing said fusion proteins, polynucleotides, vectors, host cells and virus-like particles and their use in human and veterinary medicine. 本发明涉及包含目标多肽、跨膜结构域和HIV gag多肽、或它们的功能等同变体的融合蛋白。本发明还涉及表达或呈递所述融合蛋白的多核苷酸、载体、宿主细胞和病毒样颗粒和涉及包含所述融合蛋白、多核苷酸、载体、宿主细胞和病毒样颗粒的药学、免疫原性、或疫苗组合物以及其在人类医学和兽医学中的用途。