Micromolecule polypeptide and application thereof to preparation of medicines for preventing and treating Parkinson's disease

The invention discloses micromolecule polypeptide TAT-PSYN and an application thereof to preparation of medicines for preventing or treating Parkinson's disease. Through synthesizing a TAT protein transduction domain and combining and restraining fusion protein TAT-pSyn of protein polypeptide of alpha-synuclein (alpha-synuclein), pSyn protein polypeptide carried through TAT passes through blood-brain barriers through blood transportation and is taken in by nerve cells. The polypeptide is applied to an Alpha-synuclein(A53T) transgenic Parkinson mouse model, so that the effect of the polypeptidefor blocking combination of alpha-synuclein (alpha-synuclein) and death associated protein kinase 1 (DAPK1) can be effectively exerted, loss of dopaminergic neurons and nerve projection, caused by alpha-synuclein phosphorylation and abnormal gathering can be restrained, the dyskinesia of the Parkinson model is reduced, and a molecular target is provided for medicines for clinical treatment of theParkinson's disease. 本发明公