N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof
The invention belongs to the technical field of the organic chemical industry, and particularly discloses an N-hybrid porphyrin photodynamic therapeutic agent and a synthesis method thereof. Accordingto the chemical structural formula, the synthesis method includes the steps of making 5-halogenated-...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | YAN JIAYING LIU GENJIANG LI DEJIANG ZHANG NUONUO WEN LIU LIU XIANG ZHENG KAIBO |
| description | The invention belongs to the technical field of the organic chemical industry, and particularly discloses an N-hybrid porphyrin photodynamic therapeutic agent and a synthesis method thereof. Accordingto the chemical structural formula, the synthesis method includes the steps of making 5-halogenated-2,3,3-trimethyindole and tetraphenyl N-hybrid porphyrin have a condensation reaction under the catalysis of organic acid, and obtaining the N-hybrid porphyrin photodynamic therapeutic agent through one pot at high yield. The method is characterized in that the structure with halogen is obtained efficiently through one pot, and therefore the PDT therapeutic agent with a good photodynamic treatment effect is obtained, and the singlet-state oxygen yield of the agent is in a high level.
本发明属于有机化工技术领域，特别是一种含有N-混杂卟啉的光动力治疗剂，所述化学结构式为：合成方法为以5-卤代-2,3,3-三甲基吲哚与四苯基N-混杂卟啉在有机酸催化下，经缩合反应，一锅高产率得到N-混杂卟啉光动力治疗剂。关键点在于通过一锅高效得到含卤素的结构，从而得到具有较好光动力治疗效果PDT治疗剂，其单线态氧产率处于较高水平。 |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_CN110003226A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CN110003226A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_CN110003226A3</originalsourceid><addsrcrecordid>eNqNikEKwjAQAHPxIOof1gcU0ha8S1E85eS9rM3WBOxmSdZDfm8RH-BpBma2xrkm1EeOHiRlCTVHBglJk6-MS5xAA2UUeuvq-CRWQPZQKq-hxAILaUj-u1Ga92Yz46vQ4cedOV4v9-HWkKSRiuBETDoOrm2ttX3Xnc79P88HgHE3Qg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof</title><source>esp@cenet</source><creator>YAN JIAYING ; LIU GENJIANG ; LI DEJIANG ; ZHANG NUONUO ; WEN LIU ; LIU XIANG ; ZHENG KAIBO</creator><creatorcontrib>YAN JIAYING ; LIU GENJIANG ; LI DEJIANG ; ZHANG NUONUO ; WEN LIU ; LIU XIANG ; ZHENG KAIBO</creatorcontrib><description>The invention belongs to the technical field of the organic chemical industry, and particularly discloses an N-hybrid porphyrin photodynamic therapeutic agent and a synthesis method thereof. Accordingto the chemical structural formula, the synthesis method includes the steps of making 5-halogenated-2,3,3-trimethyindole and tetraphenyl N-hybrid porphyrin have a condensation reaction under the catalysis of organic acid, and obtaining the N-hybrid porphyrin photodynamic therapeutic agent through one pot at high yield. The method is characterized in that the structure with halogen is obtained efficiently through one pot, and therefore the PDT therapeutic agent with a good photodynamic treatment effect is obtained, and the singlet-state oxygen yield of the agent is in a high level.
本发明属于有机化工技术领域，特别是一种含有N-混杂卟啉的光动力治疗剂，所述化学结构式为：合成方法为以5-卤代-2,3,3-三甲基吲哚与四苯基N-混杂卟啉在有机酸催化下，经缩合反应，一锅高产率得到N-混杂卟啉光动力治疗剂。关键点在于通过一锅高效得到含卤素的结构，从而得到具有较好光动力治疗效果PDT治疗剂，其单线态氧产率处于较高水平。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190712&DB=EPODOC&CC=CN&NR=110003226A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190712&DB=EPODOC&CC=CN&NR=110003226A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YAN JIAYING</creatorcontrib><creatorcontrib>LIU GENJIANG</creatorcontrib><creatorcontrib>LI DEJIANG</creatorcontrib><creatorcontrib>ZHANG NUONUO</creatorcontrib><creatorcontrib>WEN LIU</creatorcontrib><creatorcontrib>LIU XIANG</creatorcontrib><creatorcontrib>ZHENG KAIBO</creatorcontrib><title>N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof</title><description>The invention belongs to the technical field of the organic chemical industry, and particularly discloses an N-hybrid porphyrin photodynamic therapeutic agent and a synthesis method thereof. Accordingto the chemical structural formula, the synthesis method includes the steps of making 5-halogenated-2,3,3-trimethyindole and tetraphenyl N-hybrid porphyrin have a condensation reaction under the catalysis of organic acid, and obtaining the N-hybrid porphyrin photodynamic therapeutic agent through one pot at high yield. The method is characterized in that the structure with halogen is obtained efficiently through one pot, and therefore the PDT therapeutic agent with a good photodynamic treatment effect is obtained, and the singlet-state oxygen yield of the agent is in a high level.
本发明属于有机化工技术领域，特别是一种含有N-混杂卟啉的光动力治疗剂，所述化学结构式为：合成方法为以5-卤代-2,3,3-三甲基吲哚与四苯基N-混杂卟啉在有机酸催化下，经缩合反应，一锅高产率得到N-混杂卟啉光动力治疗剂。关键点在于通过一锅高效得到含卤素的结构，从而得到具有较好光动力治疗效果PDT治疗剂，其单线态氧产率处于较高水平。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNikEKwjAQAHPxIOof1gcU0ha8S1E85eS9rM3WBOxmSdZDfm8RH-BpBma2xrkm1EeOHiRlCTVHBglJk6-MS5xAA2UUeuvq-CRWQPZQKq-hxAILaUj-u1Ga92Yz46vQ4cedOV4v9-HWkKSRiuBETDoOrm2ttX3Xnc79P88HgHE3Qg</recordid><startdate>20190712</startdate><enddate>20190712</enddate><creator>YAN JIAYING</creator><creator>LIU GENJIANG</creator><creator>LI DEJIANG</creator><creator>ZHANG NUONUO</creator><creator>WEN LIU</creator><creator>LIU XIANG</creator><creator>ZHENG KAIBO</creator><scope>EVB</scope></search><sort><creationdate>20190712</creationdate><title>N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof</title><author>YAN JIAYING ; LIU GENJIANG ; LI DEJIANG ; ZHANG NUONUO ; WEN LIU ; LIU XIANG ; ZHENG KAIBO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN110003226A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YAN JIAYING</creatorcontrib><creatorcontrib>LIU GENJIANG</creatorcontrib><creatorcontrib>LI DEJIANG</creatorcontrib><creatorcontrib>ZHANG NUONUO</creatorcontrib><creatorcontrib>WEN LIU</creatorcontrib><creatorcontrib>LIU XIANG</creatorcontrib><creatorcontrib>ZHENG KAIBO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YAN JIAYING</au><au>LIU GENJIANG</au><au>LI DEJIANG</au><au>ZHANG NUONUO</au><au>WEN LIU</au><au>LIU XIANG</au><au>ZHENG KAIBO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof</title><date>2019-07-12</date><risdate>2019</risdate><abstract>The invention belongs to the technical field of the organic chemical industry, and particularly discloses an N-hybrid porphyrin photodynamic therapeutic agent and a synthesis method thereof. Accordingto the chemical structural formula, the synthesis method includes the steps of making 5-halogenated-2,3,3-trimethyindole and tetraphenyl N-hybrid porphyrin have a condensation reaction under the catalysis of organic acid, and obtaining the N-hybrid porphyrin photodynamic therapeutic agent through one pot at high yield. The method is characterized in that the structure with halogen is obtained efficiently through one pot, and therefore the PDT therapeutic agent with a good photodynamic treatment effect is obtained, and the singlet-state oxygen yield of the agent is in a high level.
本发明属于有机化工技术领域，特别是一种含有N-混杂卟啉的光动力治疗剂，所述化学结构式为：合成方法为以5-卤代-2,3,3-三甲基吲哚与四苯基N-混杂卟啉在有机酸催化下，经缩合反应，一锅高产率得到N-混杂卟啉光动力治疗剂。关键点在于通过一锅高效得到含卤素的结构，从而得到具有较好光动力治疗效果PDT治疗剂，其单线态氧产率处于较高水平。</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | chi ; eng |
| recordid | cdi_epo_espacenet_CN110003226A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N-hybrid porphyrin photodynamic therapeutic agent and synthesis method thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T15%3A15%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=YAN%20JIAYING&rft.date=2019-07-12&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3ECN110003226A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |