Diketopiperazine derivative and preparation and application thereof
The invention relates to the field of algaecide inhibitors, in particular to a diketopiperazine derivative derived from an endophytic fungus of seaweed, and a preparation method and application thereof to inhibition of algae. The specific structural formula is as shown in (I). According to the prepa...
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| creator | SONG YINPING JI NAIYUN |
| description | The invention relates to the field of algaecide inhibitors, in particular to a diketopiperazine derivative derived from an endophytic fungus of seaweed, and a preparation method and application thereof to inhibition of algae. The specific structural formula is as shown in (I). According to the preparation method of the diketopiperazine derivative, seaweed endophytic fungus Trichoderma asperellum A-YMD-9-2 is inoculated in a fungal culture medium for fermentation culture, and a fermentation product is separated and purified, so that the diketopiperazine derivative represented by the formula (I)is obtained. The diketopiperazine derivative obtained by the invention has a half-inhibitory concentration of the compound against microalgae up to 12 [mu]g/mL by a microalgae activity test.
本发明涉及抑藻剂领域，具体地说是一种海藻内生真菌来源的二酮哌嗪衍生物及其制备方法和在抑藻方面的应用。具体结构式如(I)所示，其制备方法为将海藻内生真菌棘孢木霉(Trichoderma asperellum)A-YMD-9-2接种于真菌培养基中发酵培养，发酵产物经分离纯化后，即为式(I)所示的二酮哌嗪衍生物。本发明获得的二酮哌嗪衍生物经抑微藻活性实验得出化合物对微藻的半数抑制浓度可达12微克/毫升。 |
| format | Patent |
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本发明涉及抑藻剂领域，具体地说是一种海藻内生真菌来源的二酮哌嗪衍生物及其制备方法和在抑藻方面的应用。具体结构式如(I)所示，其制备方法为将海藻内生真菌棘孢木霉(Trichoderma asperellum)A-YMD-9-2接种于真菌培养基中发酵培养，发酵产物经分离纯化后，即为式(I)所示的二酮哌嗪衍生物。本发明获得的二酮哌嗪衍生物经抑微藻活性实验得出化合物对微藻的半数抑制浓度可达12微克/毫升。</description><language>chi ; eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; FISHING ; FORESTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HUNTING ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEST REPELLANTS OR ATTRACTANTS ; PLANT GROWTH REGULATORS ; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF ; PROCESSES USING MICROORGANISMS ; SPIRITS ; TRAPPING ; TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE ; VINEGAR ; WINE</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190709&DB=EPODOC&CC=CN&NR=109988180A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190709&DB=EPODOC&CC=CN&NR=109988180A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SONG YINPING</creatorcontrib><creatorcontrib>JI NAIYUN</creatorcontrib><title>Diketopiperazine derivative and preparation and application thereof</title><description>The invention relates to the field of algaecide inhibitors, in particular to a diketopiperazine derivative derived from an endophytic fungus of seaweed, and a preparation method and application thereof to inhibition of algae. The specific structural formula is as shown in (I). According to the preparation method of the diketopiperazine derivative, seaweed endophytic fungus Trichoderma asperellum A-YMD-9-2 is inoculated in a fungal culture medium for fermentation culture, and a fermentation product is separated and purified, so that the diketopiperazine derivative represented by the formula (I)is obtained. The diketopiperazine derivative obtained by the invention has a half-inhibitory concentration of the compound against microalgae up to 12 [mu]g/mL by a microalgae activity test.
本发明涉及抑藻剂领域，具体地说是一种海藻内生真菌来源的二酮哌嗪衍生物及其制备方法和在抑藻方面的应用。具体结构式如(I)所示，其制备方法为将海藻内生真菌棘孢木霉(Trichoderma asperellum)A-YMD-9-2接种于真菌培养基中发酵培养，发酵产物经分离纯化后，即为式(I)所示的二酮哌嗪衍生物。本发明获得的二酮哌嗪衍生物经抑微藻活性实验得出化合物对微藻的半数抑制浓度可达12微克/毫升。</description><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>TRAPPING</subject><subject>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB2ycxOLckvyCxILUqsysxLVUhJLcosSyzJLEtVSMxLUSgoSi1ILALy8_PA_MSCgpzMZAi_JCO1KDU_jYeBNS0xpziVF0pzMyi6uYY4e-imFuTHpxYXJCan5qWWxDv7GRpYWlpYGFoYOBoTowYA5_wzWA</recordid><startdate>20190709</startdate><enddate>20190709</enddate><creator>SONG YINPING</creator><creator>JI NAIYUN</creator><scope>EVB</scope></search><sort><creationdate>20190709</creationdate><title>Diketopiperazine derivative and preparation and application thereof</title><author>SONG YINPING ; JI NAIYUN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109988180A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>TRAPPING</topic><topic>TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SONG YINPING</creatorcontrib><creatorcontrib>JI NAIYUN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SONG YINPING</au><au>JI NAIYUN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Diketopiperazine derivative and preparation and application thereof</title><date>2019-07-09</date><risdate>2019</risdate><abstract>The invention relates to the field of algaecide inhibitors, in particular to a diketopiperazine derivative derived from an endophytic fungus of seaweed, and a preparation method and application thereof to inhibition of algae. The specific structural formula is as shown in (I). According to the preparation method of the diketopiperazine derivative, seaweed endophytic fungus Trichoderma asperellum A-YMD-9-2 is inoculated in a fungal culture medium for fermentation culture, and a fermentation product is separated and purified, so that the diketopiperazine derivative represented by the formula (I)is obtained. The diketopiperazine derivative obtained by the invention has a half-inhibitory concentration of the compound against microalgae up to 12 [mu]g/mL by a microalgae activity test.
本发明涉及抑藻剂领域，具体地说是一种海藻内生真菌来源的二酮哌嗪衍生物及其制备方法和在抑藻方面的应用。具体结构式如(I)所示，其制备方法为将海藻内生真菌棘孢木霉(Trichoderma asperellum)A-YMD-9-2接种于真菌培养基中发酵培养，发酵产物经分离纯化后，即为式(I)所示的二酮哌嗪衍生物。本发明获得的二酮哌嗪衍生物经抑微藻活性实验得出化合物对微藻的半数抑制浓度可达12微克/毫升。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES USING MICROORGANISMS SPIRITS TRAPPING TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE VINEGAR WINE |
| title | Diketopiperazine derivative and preparation and application thereof |
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