Diketopiperazine derivative and preparation and application thereof

The invention relates to the field of algaecide inhibitors, in particular to a diketopiperazine derivative derived from an endophytic fungus of seaweed, and a preparation method and application thereof to inhibition of algae. The specific structural formula is as shown in (I). According to the preparation method of the diketopiperazine derivative, seaweed endophytic fungus Trichoderma asperellum A-YMD-9-2 is inoculated in a fungal culture medium for fermentation culture, and a fermentation product is separated and purified, so that the diketopiperazine derivative represented by the formula (I)is obtained. The diketopiperazine derivative obtained by the invention has a half-inhibitory concentration of the compound against microalgae up to 12 [mu]g/mL by a microalgae activity test. 本发明涉及抑藻剂领域，具体地说是一种海藻内生真菌来源的二酮哌嗪衍生物及其制备方法和在抑藻方面的应用。具体结构式如(I)所示，其制备方法为将海藻内生真菌棘孢木霉(Trichoderma asperellum)A-YMD-9-2接种于真菌培养基中发酵培养，发酵产物经分离纯化后，即为式(I)所示的二酮哌嗪衍生物。本发明获得的二酮哌嗪衍生物经抑微藻活性实验得出化合物对微藻的半数抑制浓度可达12微克/毫升。