Method for synthesizing febrifugine key chiral intermediate

The invention belongs to the technical field of chemical synthesis, relates to a method for synthesizing a febrifugine key chiral intermediate as shown in the formula 1, and particularly relates to amethod for synthesizing the febrifugine key chiral intermediate 1 (benzyl (2S, 3R)-3-tert-butyldimethylsilyloxy-2-(2-oxypropyl)piperidine-1-carboxylate). Febrifugine and febrifugine analogues have significant physiological activities, the malaria in the incubation period can be inhibited, and the environment-friendly, safe and effective protection for chicken against the coccidiosis can be carriedout. According to the method for preparing the febrifugine key chiral intermediate, the operation is simple, the route is concise, the yield is relatively high, the used reagents are commonly used reagents, the cost is low, the method is suitable for large-scale preparation, and the obtained target product can be easily converted to febrifugine, so that the method can be used for the diversity synthesis study of many natu