7-phenylacetamidodeacetoxycephalosporin G acid and preparation method thereof

The invention provides 7-phenylacetamidodeacetoxycephalosporin G acid and preparation method thereof. The method comprises the following steps: introducing a 7-phenylacetylaminodeacetoxycephalosporinG acid solution and an acid solution into a supergravity reactor for reaction, and controlling the pH value of a liquid outlet to be higher than crystallization value to prepare the 7-phenylacetylaminodeacetoxycephalosporin G acid crystal. The particle size distribution of the crystal is as follows: Dv (10) = 80-90 [mu]m, Dv (50) = 185-200 [mu]m, and Dv (90) = 360-380 [mu]m. The 7-phenylacetamidodeacetoxycephalosporin G acid crystal is produced by the continuous method, so that the problems of long preparation time, discontinuous production, poor product solubility and the like in the existingintermittent preparation process are solved; according to the method, the product quality is ensured, the product yield is improved, and the production cost is reduced. The product is more uniform ingranularity, high in cryst