Method for preparing (S)-2-(3,4-difluorophenyl)ethylene oxide

The invention relates to a method for preparing (S)-2-(3,4-difluorophenyl)ethylene oxide. The invention relates to the technical field of pharmaceutical and chemical synthesis, and discloses a methodfor producing the (S)-2-(3,4-difluorophenyl)ethylene oxide in one step through an asymmetric epoxidation reaction with a chiral Salen-manganese complex as a catalyst and 3,4-difluorostyrene as a substrate, wherein the ee value of the obtained target product is greater than 91%. The process has the advantages of short reaction steps, simple post-treatment process, low cost, mild conditions and highoptical purity of the obtained product. 一种制备(S)-2-(3，4-二氟苯基)环氧乙烷的方法。本发明涉及医药化工合成领域术领域，公开了一种以手性Salen-锰络合物作为催化剂，3，4-二氟苯乙烯为底物，经不对称环氧化反应一步生成(S)-2-(3，4-二氟苯基)环氧乙烷的方法，所得目标产物ee值﹥91％。本工艺反应步骤短，后处理过程简单，成本低，条件温和，所得产物光学纯度高。