Preparation method of key intermediate of elagolix

The invention relates to the field of pharmacy, and concretely relates to a preparation method of a key intermediate of elagolix. The method adopts simple and easily available Boc-D-phenylglycinol asa starting material, and comprises the following steps: amination, acylamidation, arylation coupling, cyclization, benzylamine substitution and deprotection. The preparation method adopting the abovesynthesis route has the advantages of simple and easily available starting material, mild reaction conditions, simplicity in post-treatment, avoiding of a noble metal catalyst, great reduction of thesynthesis cost, high purity and high yield of the obtained intermediate, and suitableness for large-scale production in the workshop. 本发明涉及制药领域，具体涉及一种噁拉戈利关键中间体的制备方法，以简单易得的Boc-D-苯甘氨醇为起始原料，包含氨基化、酰胺化、芳基化偶联、环合、苄胺取代和脱保护六步反应，该合成路线起始原料简单易得，反应条件较为温和，后处理简单，避免使用了贵金属催化剂，大大降低了工艺合成成本，得到的中间体纯度和收率也很高，非常适合车间规模化生产。