Preparation method of 3,4,5-trifluoro-2'-nitrobiphenyl

The invention discloses a preparation method of 3,4,5-trifluoro-2'-nitrobiphenyl. The method comprises the following steps: water is used as a solvent, o-chloronitrobenzene and 3,4,5-trifluorobenzeneboronic acid are subjected to a reaction in the presence of a phase transfer catalyst under the action of an acid binding agent, a catalyst and a ligand of the catalyst, and therefore the 3,4,5-trifluoro-2'-nitrobiphenyl is obtained. The method provided by the invention adopts pure water phase reaction, and has the advantages of greenness, environmental protection and convenient post-treatment. 本发明公开了一种3,4,5-三氟-2'-硝基联苯的制备方法，以水为溶剂，在相转移催化剂存在下，在缚酸剂、催化剂及其配体作用下，邻氯硝基苯和3,4,5-三氟苯硼酸反应得到3,4,5-三氟-2'-硝基联苯。本发明提供的方法采用纯水相反应，具有绿色环保、后处理方便等优点。