Valsartan and amlodipine tablets and preparation method thereof
The invention relates to valsartan and amlodipine tablets and a preparation method thereof. The valsartan and amlodipine tablets are mainly used for solving the technical problem that existing valsartan medicines are easy to decompose to produce impurities so as to influence product stability. The v...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention relates to valsartan and amlodipine tablets and a preparation method thereof. The valsartan and amlodipine tablets are mainly used for solving the technical problem that existing valsartan medicines are easy to decompose to produce impurities so as to influence product stability. The valsartan and amlodipine tablets are characterized in that core tablets comprise valsartan, amlodipine besylate, microcrystalline cellulose, crospovidone and colloidal silicon dioxide, and a wrapping layer comprises crospovidone, colloidal silicon dioxide and magnesium stearate. The valsartan is usedas a raw material, the valsartan is subjected to micronizing treatment to obtain micronized valsartan, the micronized valsartan, crospovidone XL-10 (internally added), microcrystalline cellulose PH101, amlodipine besylate and colloidal silicon dioxide (internally added) are uniformly mixed to obtain a mixture, and then the mixture is put in a dry-method pelletizer to obtain the core tablets. Thevalsartan and amlodipine t |
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