11C-labelled EGFR positron tracer and preparation method and application thereof

The invention relates to an 11C-labelled EGFR positron tracer and a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The 11C-labelled EGFR positron tracer is shown in the formula I. The tracer can completely reflect physiological and biochemical processes of clinical medication AZD9291 in cell tissue, by using the tracing effect of positron radionuclide, the pharmaceutical metabolism process in tumor cells and tissue is reflected, and the tracer has an important significance in research on tumor mechanisms, evaluation of medicinal cure effects and treatment monitoring. Especially for positron emission tomography (PET/CT), 11C-labelled AZD9291 is a developer high in practical value. 本发明涉及一种C标记的EGFR正电子示踪剂及其制备方法和应用，属于药物化学技术领域。该C标记的EGFR正电子示踪剂如式I所示，该示踪剂在细胞组织中可完全反应临床用药AZD9291的生理生化过程，利用正电子放射性核素的示踪作用，反应药物在肿瘤细胞和组织中代谢过程，对肿瘤机制研究，药物疗效评价和治疗监测具有重要的意义。特别对于正电子发射断层显像(PET/CT显像)而言，C标记AZD9291是一种具有很强实用价值的显像剂。