RGDS-modified (Arg-Gly-Asp-Ser modified) heptacyclic aldehyde and synthesis, anti-thrombus activity and application thereof

RGDS-modified (Arg-Gly-Asp-Ser modified) heptacyclic aldehyde and synthesis, anti-thrombus activity and application thereof

The invention discloses an Arg-Gly-Asp-Ser modified heptacyclic aldehyde, namely (2'S,5'S)-tetrahydropyrazino[1',2':1,6]bis{(1R-methylene-Arg-Gly-Asp-Ser)-2,3,4,9-tetrahydro-1H-pyridin[3,4-b]diindyl}-1',4'-dione and discloses its preparation method, its anti-artery thro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHI LINYI, ZHAO MING, PENG SHIQI
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses an Arg-Gly-Asp-Ser modified heptacyclic aldehyde, namely (2'S,5'S)-tetrahydropyrazino[1',2':1,6]bis{(1R-methylene-Arg-Gly-Asp-Ser)-2,3,4,9-tetrahydro-1H-pyridin[3,4-b]diindyl}-1',4'-dione and discloses its preparation method, its anti-artery thrombus activity and its application in the preparation of anti-artery thrombus drugs. 本发明公开了下式的Arg-Gly-Asp-Ser修饰的七环醛,即(2'S,5'S)-四氢吡嗪[1',2':1,6]并双{(1R-亚甲基-Arg-Gly-Asp-Ser)-2,3,4,9-四氢-1H-吡啶[3,4-b]并吲哚}-1',4'-二酮,公开了它的制备方法,公开了它的抗动脉血栓活性，因而本发明公开了它在制备抗动脉血栓药物中的应用。