Anti-inflammatory drug and use thereof

The invention discloses an anti-inflammatory drug and use thereof. The drug comprises a chiral compound of formula I, or a pharmaceutically acceptable salt, solvate or deuterate thereof; W and Z are independently selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, C1-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SU LONGWEN, ZHOU YANG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention discloses an anti-inflammatory drug and use thereof. The drug comprises a chiral compound of formula I, or a pharmaceutically acceptable salt, solvate or deuterate thereof; W and Z are independently selected from hydrogen, substituted or unsubstituted C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, monocyclic aryl, monocyclic aryloxy or monocyclic heteroaryl; the substitution means that the substance is substituted by one or more groups selected from halogen, C1-C6 alkyl, nitro, amino or hydroxyl; ring A is selected from monocyclic or bicyclic heteroaryl, C3-C6 lactonic ring, C3-C6 lactam ring and C3-C6 thiolactone ring; and alpha and beta are two chiral sites in the compound, and an absolute configuration of alpha and beta are each independently selected froman S or R configuration. The compound disclosed by the invention has remarkable anti-inflammatory effects and is expected to become a new type of non-steroidal anti-inflammatory drugs. 本发明公开一种抗炎药物及其用途。该药物含有式I的手性化合物,或其药学上可接受的盐