Flaky calcium phosphate vaccine adjuvant and preparation method thereof

The invention discloses a flaky calcium phosphate vaccine adjuvant and a preparation method thereof. The preparation method refers that: (1) a certain amount of chitosan is dissolved in water, the PHis adjusted with hydrochloric acid until the chitosan is dissolved completely, a certain amount of 3,4-dihydroxyphenylpropionic acid and carbodiimide (EDC) are dissolved in ethanol and water respectively and the two mixtures are mixed evenly, the mixture is added to chitosan solution under rapid stirring and the pH is adjusted to about 5.5 with sodium hydroxide, the action is performed for a certain time, and the obtained mixture is dialyzed and freeze-dried to prepare catechol-modified chitosan (CSC). (2) The protein mimic antigen is added into the CSC aqueous solution and stirred and mixed evenly; then, phosphate buffer solution is added, and the mixture is stirred for a period of time, then the obtained mixture is added to CaCl2 aqueous solution and stirred for the same time, and is centrifuged and washed to ob