Synthesis method of medium-chain triglyceride

The invention relates to the technical field of medicines, aims to solve the problem of low yield of medium-chain triglyceride, and provides a synthesis method of the medium-chain triglyceride; the synthesis method comprises the following steps: S1, fatty acid and glycerol are mixed according to the...

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Hauptverfasser: ZHANG HEMING, LI XIAOLEI, CAI YUNFENG, ZOU XIAOYAN, ZHOU RENXUE
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to the technical field of medicines, aims to solve the problem of low yield of medium-chain triglyceride, and provides a synthesis method of the medium-chain triglyceride; the synthesis method comprises the following steps: S1, fatty acid and glycerol are mixed according to the mass part ratio of 1: 1-1.5; and S2, the temperature is controlled to be 160-180 DEG C, and the catalyst is added, so that the fatty acid and the glycerol are subjected to an esterification reaction. The ratio of fatty acid to glycerol is controlled to be 1: 1-1.5, and meanwhile, the temperature ofthe esterification reaction is controlled to be 160-180 DEG C, so that the esterification reaction is fully carried out, the conversion rate of the esterification reaction is improved, and the yieldis further improved. 本发明涉及医药技术领域,针对中链甘油三酸酯的产率低的问题,提供了一种中链甘油三酸酯的合成方法,包括以下步骤:S1、脂肪酸与甘油按质量份数比为1:1-1.5混合;S2、控制温度为160℃-180℃,加入催化剂,使得脂肪酸与甘油发生酯化反应。通过控制脂肪酸与甘油的比例为1:1-1.5,同时控制酯化反应的温度为160℃-180℃,有利于酯化反应的充分进行,使得酯化反应的转化率提高,进而有利于提高产率。