c-Myc gene expression inhibitor and application thereof

The invention discloses a c-Myc gene expression inhibitor, and application thereof to preparing anti-tumor medicines. The c-Myc gene expression inhibitor is a pyrrole-imidazole polyamide small molecule. The pyrrole-imidazole polyamide small molecule is targeted to a c-Myc gene promoter sequence through a recognizing and pairing mode, and the expression of a c-Myc gene is silenced. Polyamide PA6 presents good tumor cytotoxicity, the growth of tumor cells can be restrained, and the apoptosis of the tumor cells is induced. 本发明公开了一种c-Myc基因表达抑制剂，及其在制备抗肿瘤药物中的应用。本发明的c-Myc基因表达抑制剂为吡咯咪唑聚酰胺小分子，所述吡咯咪唑聚酰胺小分子通过识别配对的方式靶向c-Myc基因启动子序列，并且沉默c-Myc基因的表达，本发明的聚酰胺PA6体现出较好的肿瘤细胞毒性，并且能够抑制肿瘤细胞的生长，诱导肿瘤细胞凋亡。