2-difluoroethyl-1-indanone derivative and preparation method thereof

The invention discloses a 2-difluoroethyl-1-indanone derivative and a preparation method thereof. The preparation method comprises the following steps: adding and mixing o-propargylbenzaldehyde with astructure as shown in formula II, monobromodifluoride with a structure as shown in formula III, tris (2-phenylpyridine) iridium, potassium phosphate and a solvent to form a reaction system under bluelight irradiation; after the reaction is finished, carrying out aftertreatment to obtain the 2-difluoroethyl-1-indanone derivative with the structure as shown in formula I. According to the invention, the stereoselective synthesis of 2-difluoroethyl-1-indanone is realized in one step through a difluoromethylene/cyclization series reaction strategy. The reaction condition is mild, the applicationrange of a substrate is wide, the reaction yield is good, the preparation method is simple to operate, and a new way for synthesizing a fluorine-containing 1-indenone compound is provided. 本发明公开了一种2-二氟乙基-1-茚酮衍生物及制备方法，将式Ⅱ结构的邻炔丙基