Organ preserving liquid

The invention provides a method for maintaining the survival and/or function of vascular endothelial cells in the in vitro preservation process and used preserving fluid. The method and the preservingfluid are suitable for storing various organs. The in vitro liver can survive to exceed 24h during t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: XU LILI, HUANG DEFENG, SHEN HEFANG, ZHAO LIJUAN, BIAN CONGWEN, XU JIANJIAN, DAI YAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention provides a method for maintaining the survival and/or function of vascular endothelial cells in the in vitro preservation process and used preserving fluid. The method and the preservingfluid are suitable for storing various organs. The in vitro liver can survive to exceed 24h during the preservation by the organ preserving liquid and in the mechanical filling process; the liver microcirculation structure is complete; no obvious damage exists; the choleresis function is good; the liver synthesis and metabolism functions are good; the in vitro preservation time of the liver is greatly prolonged; the postoperative survival rate of later-period liver transplantation patients is improved. 本发明提供一种维持血管内皮细胞体外保存过程中存活和/或功能的方法以及所用的保存液,适用于多种器官保存。离体肝脏在本发明所述器官保存液保存以及机械灌注过程中能够存活超过24h,肝脏微循环结构完整,未见明显损伤,胆汁分泌功能良好,肝脏合成与代谢功能良好,大大延长肝脏体外保存的时间,并提升后期肝移植患者术后生存率。