Preparation method of novel terephthalaldehyde-condensed D-glucosamine Schiff base

The invention discloses a preparation method of a novel terephthalaldehyde-condensed D-glucosamine Schiff base. The preparation method comprises the following steps of weighing D-glucosamine hydrochloride in a beaker, adding anhydrous methanol, then adding sodium hydroxide for reaction, filtering to remove NaCl, adding an anhydrous methanol solution of terephthalaldehyde in a filtrate slowly, conducting reaction under water bath conditions at 35 DEG C, standing overnight, precipitating solid powder, filtering, washing with cold anhydrous methanol for several times, conducting vacuum drying toobtain terephthalaldehyde-condensed D-glucosamine Schiff base. Such compounds have good water solubility, good optical properties and certain antibacterial activity, can be used as a fluorescent probefor tumor cell imaging, and can expand the application range of Schiff base fluorescent dyes. 本发明公开一种新型对苯二甲醛缩D-氨基葡萄糖席夫碱的制备方法，包括如下步骤：称取D-氨基葡萄糖盐酸盐放入烧杯中，加入无水甲醇，再加入氢氧化钠反应，过滤除去NaCl，向滤液缓慢滴加对苯二甲醛的无水甲醇溶液，于35℃水浴条件下反应后冷却，放置一夜，析出固体粉末，过滤