1,8-dihydroxyl-9,10-anthraquinone derivative and preparation method and application thereof

The invention discloses a 1,8-dihydroxyl-9,10-anthraquinone derivative and a preparation method and application thereof and provides application of a 1,8-dihydroxyl-9,10-anthraquinone derivative shownin a formula I or a pharmaceutically acceptable salt of the 1,8-dihydroxyl-9,10-anthraquinone derivative to preparation of medicines for treatment and/or prevention of hepatitis C. The formula I is as shown in the specification, wherein R refers to C1-C6 alkoxy carbonyl, R substituted or non-substituted benzenesulfonyl, or R substituted or non-substituted benzyl, and R and R are C1-C4alkyl or C1-C4 alkoxy independently. The 1,8-dihydroxyl-9,10-anthraquinone derivative is high in anti-HCV activity. 本发明公开了一种1，8-二羟基-9，10-蒽醌衍生物、其制备方法及应用。本发明提供了一种如式I所示的1，8-二羟基-9，10-蒽醌衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎药物中的应用；其中，R为C～C烷氧基羰基、R取代或未取代的苯磺酰基、或、R取代或未取代的苄基；所有的R和R独立地为C～C烷基、或、C～C烷氧基。本发明提供的1，8-二羟基-9，10-蒽醌衍生物显示了较好的抗HCV活性。