Emodin derivative, preparation method thereof and application
The invention discloses an emodin derivative, a preparation method thereof and application, and provides application of the emodin derivative shown in the formula I or pharmaceutically acceptable saltto preparation of medicine for treating and/or preventing hepatitis C. R is an alkyl group of C2-C6...
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| creator | YUAN HU LI YUZHU LUO XUKAI SUN QING WU TONG OUYANG DANWEI ZHANG WEIDONG |
| description | The invention discloses an emodin derivative, a preparation method thereof and application, and provides application of the emodin derivative shown in the formula I or pharmaceutically acceptable saltto preparation of medicine for treating and/or preventing hepatitis C. R is an alkyl group of C2-C6 or vinyl of R1 substituted or non-substituted C2-C4; all R1 is independently C1-C4 alkyl groups. The emodin derivative has good anti-HCV activity.
本发明公开了一种大黄素衍生物、其制备方法及应用。本发明提供了一种如式I所示的大黄素衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎的药物中的应用；其中，R为C～C的烷基、或、R取代或未取代的C～C的烯基；所有的R独立地为C～C烷基。本发明提供的大黄素衍生物显示了较好的抗HCV活性。 |
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本发明公开了一种大黄素衍生物、其制备方法及应用。本发明提供了一种如式I所示的大黄素衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎的药物中的应用；其中，R为C～C的烷基、或、R取代或未取代的C～C的烯基；所有的R独立地为C～C烷基。本发明提供的大黄素衍生物显示了较好的抗HCV活性。</description><language>chi ; eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2019</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190514&DB=EPODOC&CC=CN&NR=109745302A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20190514&DB=EPODOC&CC=CN&NR=109745302A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YUAN HU</creatorcontrib><creatorcontrib>LI YUZHU</creatorcontrib><creatorcontrib>LUO XUKAI</creatorcontrib><creatorcontrib>SUN QING</creatorcontrib><creatorcontrib>WU TONG</creatorcontrib><creatorcontrib>OUYANG DANWEI</creatorcontrib><creatorcontrib>ZHANG WEIDONG</creatorcontrib><title>Emodin derivative, preparation method thereof and application</title><description>The invention discloses an emodin derivative, a preparation method thereof and application, and provides application of the emodin derivative shown in the formula I or pharmaceutically acceptable saltto preparation of medicine for treating and/or preventing hepatitis C. R is an alkyl group of C2-C6 or vinyl of R1 substituted or non-substituted C2-C4; all R1 is independently C1-C4 alkyl groups. The emodin derivative has good anti-HCV activity.
本发明公开了一种大黄素衍生物、其制备方法及应用。本发明提供了一种如式I所示的大黄素衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎的药物中的应用；其中，R为C～C的烷基、或、R取代或未取代的C～C的烯基；所有的R独立地为C～C烷基。本发明提供的大黄素衍生物显示了较好的抗HCV活性。</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2019</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB1zc1PycxTSEktyixLLMksS9VRKChKLUgsAnLy8xRyU0sy8lMUSjJSi1Lz0xQS81IUEgsKcjKTwdI8DKxpiTnFqbxQmptB0c01xNlDN7UgPz61uCAxOTUvtSTe2c_QwNLcxNTYwMjRmBg1AEGaMHc</recordid><startdate>20190514</startdate><enddate>20190514</enddate><creator>YUAN HU</creator><creator>LI YUZHU</creator><creator>LUO XUKAI</creator><creator>SUN QING</creator><creator>WU TONG</creator><creator>OUYANG DANWEI</creator><creator>ZHANG WEIDONG</creator><scope>EVB</scope></search><sort><creationdate>20190514</creationdate><title>Emodin derivative, preparation method thereof and application</title><author>YUAN HU ; LI YUZHU ; LUO XUKAI ; SUN QING ; WU TONG ; OUYANG DANWEI ; ZHANG WEIDONG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN109745302A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2019</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>YUAN HU</creatorcontrib><creatorcontrib>LI YUZHU</creatorcontrib><creatorcontrib>LUO XUKAI</creatorcontrib><creatorcontrib>SUN QING</creatorcontrib><creatorcontrib>WU TONG</creatorcontrib><creatorcontrib>OUYANG DANWEI</creatorcontrib><creatorcontrib>ZHANG WEIDONG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YUAN HU</au><au>LI YUZHU</au><au>LUO XUKAI</au><au>SUN QING</au><au>WU TONG</au><au>OUYANG DANWEI</au><au>ZHANG WEIDONG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Emodin derivative, preparation method thereof and application</title><date>2019-05-14</date><risdate>2019</risdate><abstract>The invention discloses an emodin derivative, a preparation method thereof and application, and provides application of the emodin derivative shown in the formula I or pharmaceutically acceptable saltto preparation of medicine for treating and/or preventing hepatitis C. R is an alkyl group of C2-C6 or vinyl of R1 substituted or non-substituted C2-C4; all R1 is independently C1-C4 alkyl groups. The emodin derivative has good anti-HCV activity.
本发明公开了一种大黄素衍生物、其制备方法及应用。本发明提供了一种如式I所示的大黄素衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎的药物中的应用；其中，R为C～C的烷基、或、R取代或未取代的C～C的烯基；所有的R独立地为C～C烷基。本发明提供的大黄素衍生物显示了较好的抗HCV活性。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Emodin derivative, preparation method thereof and application |
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