Emodin derivative, preparation method thereof and application

The invention discloses an emodin derivative, a preparation method thereof and application, and provides application of the emodin derivative shown in the formula I or pharmaceutically acceptable saltto preparation of medicine for treating and/or preventing hepatitis C. R is an alkyl group of C2-C6 or vinyl of R1 substituted or non-substituted C2-C4; all R1 is independently C1-C4 alkyl groups. The emodin derivative has good anti-HCV activity. 本发明公开了一种大黄素衍生物、其制备方法及应用。本发明提供了一种如式I所示的大黄素衍生物或其药学上可接受的盐在制备用于治疗和/或预防丙型肝炎的药物中的应用；其中，R为C～C的烷基、或、R取代或未取代的C～C的烯基；所有的R独立地为C～C烷基。本发明提供的大黄素衍生物显示了较好的抗HCV活性。