INHIBITORS OF THE MENIN-MLL INTERACTION

The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancerand other diseases mediated by the menin-MLL interaction. 本发明涉及menin与MLL和MLL融合蛋白的相互作用的抑制剂、含有该抑制剂的药物组合...

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Bibliographische Detailangaben
Hauptverfasser:	MARCUS ANDREW, LOTESTA STEPHEN D, HOUSTON TRAVIS L, ZHENG YAJUN, ZHUANG LINGHANG, JIA LANQI, PARENT STEPHAN D, CLAREMON DAVID A, FAN YI, YUAN JING, CACATIAN SALVACION, DONG CHENGGUO, SINGH SURESH B, MORALES-RAMOS ANGEL, DILLARD LAWRENCE WAYNE, VENKATRAMAN SHANKAR
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancerand other diseases mediated by the menin-MLL interaction. 本发明涉及menin与MLL和MLL融合蛋白的相互作用的抑制剂、含有该抑制剂的药物组合物，以及它们在治疗癌症和由menin-MLL相互作用介导的其它疾病中的用途。