3-phenyl-7,8-dehydrogenated vitis amurensis vine pentosidine derivatives as well as preparation method and pharmaceutical composition thereof and application of derivatives and pharmaceutical composition

The invention discloses a novel class of 3-phenyl-7,8-dehydrogenated vitis amurensis vine pentosidine (amurensin H) derivatives with anti-inflammatory activity and anti-inflammatory activity thereof.Specifically, the invention relates to the 3-aryl-4 substituted benzofuran derivatives with a novel s...

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Hauptverfasser:	BAI JINYE, YAO CHUNSUO, ZHANG JIFA, SHI JIANGONG, HOU QI, LIN MINGBAO, FAN YANNAN, TENG BINHAO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The invention discloses a novel class of 3-phenyl-7,8-dehydrogenated vitis amurensis vine pentosidine (amurensin H) derivatives with anti-inflammatory activity and anti-inflammatory activity thereof.Specifically, the invention relates to the 3-aryl-4 substituted benzofuran derivatives with a novel structure represented by a general formula (I) shown in the description or a medically-acceptable salt of the derivatives. The invention discloses an application of the derivative monomers or the pharmaceutical composition of the derivatives in clinical treatment of inflammatory related diseases. 本发明公开了一类具有抗炎活性的新型3-苯基-7,8-脱氢葡萄藤戊素(Amurensin H)衍生物及其抗炎活性。具体涉及到一类如通式(I)所示新型结构的3-芳基-4取代苯并呋喃衍生物或其医学上可接受的盐。本发明公开了这类衍生物单体或药用组合物在炎症性相关疾病的临床治疗中的应用。