Plumbagin selenium ester derivative, and preparation method and applications thereof

The invention discloses a plumbagin selenium ester derivative shown as a formula (V) and a preparation method thereof. The preparation method includes dissolving sodium hydride into a solvent under N2atmosphere and 0-5 DEG C conditions; adding plumbagin to stir for 10-30 min; then adding isoselenocyanate to perform reaction for 3-5 h; and obtaining the derivative through post-treatment. The preparation method is simple in technology; and the obtained derivative has good targeting selectivity and inhibitory activity on hepatocellular and colorectal cancer cells, and can be applied to prepare antineoplastic activity drugs, so that more effective approaches can be provided for the treatment of related diseases, and the derivative has extremely wide application prospects in a drug developmentsystem. The plumbagin selenium ester derivative is shown as the formula (V). 本发明公开了种如下式(V)所示的兰雪醌硒酯衍生物及其制备方法，所述兰雪醌硒酯衍生物的制备方法为：在N气氛及0～5℃条件下，将氢化钠溶于溶剂，加入兰雪醌搅拌10～30min，再加入异硒氰酸酯反应3～5h，最后经过后处理得到。本发明制备方法工艺简单，得到的兰雪醌硒酯衍生物对肝癌细胞和结直肠癌细胞的具