Heteroaromatic derivatives as NIK inhibitors

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of NF-[kappa]B-inducing kinase (NIK - also known as MAP3K14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, and to the use of such compounds or pharmaceutical compositions for the prevention or treatment of diseases such as cancer, inflammatory disorders, metabolic disorders including obesity and diabetes, and autoimmune disorders. 本发明涉及可用于哺乳动物的治疗和/或预防的式(I)药剂，特别是涉及可用于治疗诸如癌症、炎性病症、代谢紊乱和自身免疫病症等疾病的NF-κB诱导激酶(NIK--也称为MAP3K14)的抑制剂。本发明还涉及包含此类化合物的药物组合物，以及这类化合物或药物组合物在预防或治疗诸如癌症、炎性病症、包括肥胖和糖尿病在内的代谢紊乱和自身免疫病症等疾病中的用途。