METHOD OF PRODUCING FLUORINE-CONTAINING PYRAZOLE CARBOXYLIC ACID HALIDE

The present invention provides a production method that is capable of more simply and efficiently producing a fluorine-containing pyrazole carboxylic acid halide that is useful as a pharmaceutical oragrochemical intermediate. The present invention relates to a method of producing a compound represen...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MATSUMURA YASUSHI, YOKOKOJI OSAMU, SHIMIZU TAMAKI, ISHIBASHI YUICHIRO
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention provides a production method that is capable of more simply and efficiently producing a fluorine-containing pyrazole carboxylic acid halide that is useful as a pharmaceutical oragrochemical intermediate. The present invention relates to a method of producing a compound represented by formula (a) by reacting a compound represented by formula (c) and a halogenating agent in anon-aqueous system. (In the formulas, R1 is a fluoroalkyl group comprising 1-3 carbon atoms, R2 is a hydrogen atom or an alkyl group comprising 1-6 carbon atoms, R3 is an alkyl group comprising 1-6 carbon atoms, and X is a halogen atom). 本发明提供能够更简单且高效地制备作为药物或农药中间体而言有用的含氟吡唑羧酸酰卤类的方法。本发明涉及制备式(a)所示的化合物的方法,其包括:在非水性体系中使式(c)所示的化合物与卤化剂反应;其中,R是具有1~3个碳原子的氟烷基,R是氢原子或具有1~6个碳原子的烷基,R是具有1~6个碳原子的烷基,X是卤素原子。