Application of plasma/serum exosome miRNA as diagnostic marker for glaucoma

The invention discloses application of has-miR-21-5p and/or has-miR-15b-5p and/or has-miR-424-5p as a diagnostic marker for glaucoma. Research experiments show that the has-miR-21-5p and/or the has-miR-15b-5p and/or the has-miR-424-5p are up-regulated in expression of exosomes isolated from blood of...

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Hauptverfasser:	GUAN JITIAN, CHI ZAILONG, ZHANG WENMENG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses application of has-miR-21-5p and/or has-miR-15b-5p and/or has-miR-424-5p as a diagnostic marker for glaucoma. Research experiments show that the has-miR-21-5p and/or the has-miR-15b-5p and/or the has-miR-424-5p are up-regulated in expression of exosomes isolated from blood of a patient with primary glaucoma. The application of the has-miR-21-5p and/or the has-miR-15b-5p and/or the has-miR-424-5p expression level products in the preparation of a diagnostic tool for the glaucoma is provided. 本发明公开了种hsa-miR-21-5p和/或hsa-miR-15b-5p和/或hsa-miR-424-5p作为青光眼诊断标志物中的应用，研究实验表明hsa-miR-21-5p和/或hsa-miR-15b-5p和/或hsa-miR-424-5p在原发性青光眼患者的血液分离出的外泌体中表达上调，本发明提供了hsa-miR-21-5p和/或hsa-miR-15b-5p和/或hsa-miR-424-5p表达水平的产品在制备青光眼疾病诊断工具中的应用。